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Neuropathy (also called peripheral neuropathy) is a painful disorder that affects people with a wide variety of conditions. It occurs when pressure on a peripheral nerve blocks that nerve’s signal to the brain. Although the causes of neuropathy vary, some common associated conditions are alcoholism, tumors and benign growths, exposure to toxins or heavy metals, extreme vitamin B deficiencies, physical trauma or repetitive stress, HIV or AIDS, hypothyroidism, Lyme disease, and diseases that affect kidney and liver function. People with neuropathy may experience pain in the feet or ankles, numbness and tingling in the limbs or extremities, inflammation in the calf muscle or shoulder and knee joints, headaches and fatigue, tremors, or physical weakness. Sometimes, these and other symptoms combine in a way that seems unrelated, which can make diagnosis challenging. Neuropathy can happen anywhere in the body; in some cases, it can be hard to narrow down the exact cause of neuropathy, which is why it is important to consult a pain management specialist to determine the best course of action.